Welcome to MiREDiBase (miRNA Editing Database), a catalog of validated and putative miRNA editing sites from literature and an online resource for functional prediction of miRNA editing. Here, users can explore multiple features related to miRNA modification events, such as detection and validation methods, experiment type, biological sources, enzyme affinity, and much more. Have fun!

About miRNA Editing

RNA editing refers to enzymatic modifications occurring on specific nucleosides of an RNA molecule. MiRNA editing, in particular, refers to RNA modification events occurring in miRNA transcripts, which currently represent the best characterized class of regulatory small non-coding RNAs. The importance of miRNA editing consists in the fact that such an event often results in the blockage of miRNA biogenesis or in the alteration of its mature sequence, likely causing a functional shift. This would then lead towards various implications on the cell physiopathology.

About the Database

Besides being a tool for the study of miRNA editing, MiREDiBase also provides useful information for the study of modified miRNAs as potential biomarkers of specific physiopathological conditions. It allows the users to infer associations between specific modification events and organ dysfunctions, the biological function of modified mature miRNAs, and to compare editing levels between matched normal and adverse conditions.

The current version of the database contains information on validated and putative A-to-I (Adenosine-to-Inosine) and C-to-U (Cytosine-to-Uracil) miRNA modifications in humans and primates.